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Post-doctoral positions at the Cancer Research Center of Lyon (CRCL)



2-3 year post-doctoral position in Immunology


The laboratory of Prof Julien C. Marie is seeking an experienced, creative and post-doctoral fellow to study the effects of TGF-b on T cell-biology in autoimmunity and anti-cancer response. A particular focus is proposed on deciphering mechanisms of action of TGF-b in using both in vitro and in vivo mouse models.


Lab publications related to the topic: Marie et al Immunity 2006, Doisne et al J.Exp. Med 2009, Havenar Blood 2012, Ruiz et al Nature Com 2014, Mc Carron J.Clin invest 2014, Worthington et al Immunity 2015. Bauché et al Science Trans Med 2016, Mc Carron et al Nature Com 2019. Bonnet et al Cancer Research, Pereira et al Nature Immunol 2020.


The selected candidate will join a dynamic research team composed of 10-12 people.

  • Candidates hould have solid expertise in immunology and flow cytometry

  • Expertise on human samples is an assetbut not requested.

  • Expertise in gut or skin immune system will be highly considered

  • Salary will be covered by the lab and will depend on the expertise of the candidate.35000 -55000 euros

  • Tenure track position can be set up

  • The Marie lab is settled at the CRCL, on the site of léon Berard cancer hospital, in Lyon, France, offering up-to-date infrastructures in a stimulating scientific environment composed of more than 500 scientists. With spectral flow cytometry facility , single cell facility, bi-photon microscopy...

  • English isthe language of the lab

Candidates should provide a curriculum vitae, a letter of motivation to julien.marie@inserm.fr (email subject: post-doctoral position at the Marie lab). Selected candidates will be contacted for interview and the position can start rapidly.


Post-Doctoral position “Hepatitis B virus cure” program


The research laboratory on Viral Hepatitis at INSERM Unit 1052 (Cancer Research Center of Lyon –CRCL) is opening a Post-Doctoral position to work on its “HBV cure” program. The Viral Hepatitis Team has a longstanding experience in the study of the mechanisms of HBV persistence and the identification of novel targets for antiviral therapy. The laboratory is looking for a motivated candidate to work on a project focused on the characterization of novel approaches to directly target the viral minichromosome, the so-called covalently closed circular DNA (cccDNA), responsible for HBV persistence in infected cells. In particular, the project is aimed at the investigation of the use of nuclease-based strategies to hit cccDNA.

The project is integrated in a wider, international program on “HBV cure”, in which the laboratory is actively involved (1, 2). Relevant in vitro and in vivo models for the study of human HBV infection and expertise in molecular virology and epigenetics are well established in the host laboratory. The candidate will also benefit from the scientific environment and technical platforms provided by the CRCL (http://www.crcl.fr). The position is available immediately.

The highly motivated candidate will have to hold a PhD and be experienced in cell culture and molecular biology. Experience in molecular virology and/or genome editing technology will be welcome.

The candidates should send their application (C.V., letter of motivation and 2 letters of recommendation) to:

Prof. Fabien Zoulim

Head of Viral Hepatitis Laboratory, INSERM U1052

e-mail: fabien.zoulim@inserm.fr; marieagnes.vittoz@inserm.fr


References

1) Fanning GC, Zoulim F, Hou J, Bertoletti A. Therapeutic strategies for hepatitis B virus infection: towards a cure. Nat Rev Drug Discov. 2019

2) Martinez MG, Boyd A, Combe E, Testoni B, Zoulim F. Covalently closed circular DNA: the ultimate therapeutic target for curing Hepatitis B virus infections. J Hepatol. 2021